Excellent R&D experts in Cell2in seek to develop
innovative cell therapy and future medical technology

We aim to become the global biotech company
based on proprietary technology.

R&D based company with mass cell culture technology and cell quality management technology

Patented in countries
leading new drug development market

Enter the global biotech market
with Proprietary technology

Intellectual Property

Cell2in is committed to protect our core technology by establishment of intellectual property in the field of cell therapy

Name of Technology Country of Application Application and Registration No. Applied and Registered Date
Real-time Imaging Sensor for Measuring Cellular Thiol Levels Korea 10-1862581 2018. 05. 24
United States 10.215.757B2 2019. 02. 26
Korea 10-1983803 2019. 05. 23
United States 10.620.215 2020. 04. 14
Real-time Fluorescence Imaging Sensor for Estimating the Glutathione in Cellular Organelle and Manufacturing Method Thereof Korea 10-2133794 2020. 07. 08
Canada (application) 3.072.434 2020. 02. 07
Australia (application) 2018320601 2020. 02. 19
United States (application) 16/640717 2020. 02. 20
Europe (application) 18848372.1 2020. 02. 21
China (application) 201880054675.0 2020. 02. 21
India (application) 202017007994 2020. 02. 25
Japan (application) 2020-511502 2020. 02. 19
Real-time Fluorescence Imaging Sensor for Estimating the Glutathione in Endoplasmic Reticulum and a Method of Using It Korea 10-2019-0178260 2019. 12. 30

Gene Biomarker

Name of Technology Country of Application Application and Registration No. Applied and Registered Date
FreSHtracer-based Application of the Genetic Profile of Separated Cells PCT PCT/KR 2018/008239 2018. 07. 20

Stem Cell Therapy

Name of Technology Country of Application Application and Registration No. Applied and Registered Date
Composite for Treatment of Thrombocytopenia Korea 10-2021-0063975 2021. 05. 18
Gene Market for Evaluating the Characteristics of Stem Cells and the Use of the Same Korea 10-2020-0180455 2020. 12. 22

Cell Quality Control

Name of Technology Country of Application Application and Registration No. Applied and Registered Date
Method of Therapeutic Cell Quality Improvement Based on Real-time Glutathione Measurement Korea 10-2119714 2020. 06. 01
Europe (application) 18883520.1 2020. 05. 27
China (application) 201880077266.2 2020. 05. 28
Japan (application) 2020-546264 2020. 05. 27
United States (application) 16/767985 2020. 05. 28
Method of Therapeutic Cell Quality Measurement Based on Real-time Glutathione Measurement Korea 10-2145929 2020. 08. 12
United States (application) 16/768014 2020. 05. 28
Europe (application) 18884812.1 2020. 05. 27
China (application) 201880077236.1 2020. 05. 28
Japan (application) 2020-546265 2020. 05. 27

Publication

Cell2in has continuously published its research results through famous academic societies and journals.

Principles of Development Technology : EM. Jeong et al., Real-Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function, Stem Cell Reports (2018), 10, 600-614

The core functions of stem cells (SCs) are critically regulated by their cellular redox status. Glutathione is the most abundant non-protein
thiol functioning as an antioxidant and a redox regulator. However, an investigation into the relationship between glutathione-mediated
redox capacity and SC activities is hindered by lack of probe. Here, we demonstrate that cyanoacrylamide-based coumarin derivatives are
ratiometric probes suitable for the real-time monitoring of glutathione levels in living SCs. These probes revealed that glutathione levels
are heterogeneous among subcellular organelles and among individual cells and show dynamic changes and heterogeneity in repopulating
SCs depending on oxidative stress or culture conditions. Importantly, a subpopulation of SCs with high glutathione levels exhibited
increased stemness and migration activities in vitro and showed improved therapeutic efficiency in treating asthma. Our results indicate
that high glutathione levels are required for maintaining SC functions, and monitoring glutathione dynamics and heterogeneity can
advance our understanding of the cellular responses to oxidative stress.