셀투인은 연구개발 결과를 특허등록, 학술지 게재 및 국제학회 기술 발표를 통해
기술의 우수성과 신뢰성을 입증하고 있습니다.
지적재산권 확보
Cell2in은 글로벌 바이오 시장에서 고유 기술을 활용한 적극적 사업 전개를 위해 국내는 물론 신약개발 주요국가의 고품질 세포치료제 생산기술의 특허를 확보하고 있습니다.
물질 및 용도
Name of Technology | Country of Application | Application and Registration No. | Applied and Registered Date |
---|---|---|---|
세포의 티올수준을 측정하기 위한 실시간 이미징 센서 |
Korea | 10-1862581 | 2018. 05. 24 |
United States | 10.215.757B2 | 2019. 02. 26 | |
Korea | 10-1983803 | 2019. 05. 23 | |
United States | 10.620.215 | 2020. 04. 14 | |
세포의 소기관 내 글루타치온 측정용 실시간 형광 이미징 센서 및 이의 제조방법 |
Korea | 10-2133794 | 2020. 07. 08 |
Canada (application) | 3.072.434 | 2020. 02. 07 | |
Australia (application) | 2018320601 | 2020. 02. 19 | |
United States (application) | 16/640717 | 2020. 02. 20 | |
Europe (application) | 18848372.1 | 2020. 02. 21 | |
China (application) | 201880054675.0 | 2020. 02. 21 | |
India (application) | 202017007994 | 2020. 02. 25 | |
Japan (application) | 2020-511502 | 2020. 02. 19 | |
소포체 내 글루타치온 측정용 실시간 형광 이미지 센서 및 이를 이용하는 방법 |
Korea | 10-2019-0178260 | 2019. 12. 30 |
Gene Biomarker
Name of Technology | Country of Application | Application and Registration No. | Applied and Registered Date |
---|---|---|---|
FreSHtracer 기반 분리된 세포의 유전자 프로파일의 응용 |
PCT | PCT/KR 2018/008239 | 2018. 07. 20 |
Stem Cell Therapy
Name of Technology | Country of Application | Application and Registration No. | Applied and Registered Date |
---|---|---|---|
혈소판 감소증 치료용 조성물 |
Korea | 10-2021-0063975 | 2021. 05. 18 |
고품질의 줄기세포 선별용 마커 및 이를 이용한 고품질 줄기세포 선별 방법 |
Korea | 10-2020-0180455 | 2020. 12. 22 |
Cell Quality Control
Name of Technology | Country of Application | Application and Registration No. | Applied and Registered Date |
---|---|---|---|
실시간 글루타치온 측정을 통한 치료용 세포의 품질 향상 방법 |
Korea | 10-2119714 | 2020. 06. 01 |
Europe (application) | 18883520.1 | 2020. 05. 27 | |
China (application) | 201880077266.2 | 2020. 05. 28 | |
Japan (application) | 2020-546264 | 2020. 05. 27 | |
United States (application) | 16/767985 | 2020. 05. 28 | |
실시간 글루타치온 측정을 통한 치료용 세포의 품질 측정 방법 |
Korea | 10-2145929 | 2020. 08. 12 |
United States (application) | 16/768014 | 2020. 05. 28 | |
Europe (application) | 18884812.1 | 2020. 05. 27 | |
China (application) | 201880077236.1 | 2020. 05. 28 | |
Japan (application) | 2020-546265 | 2020. 05. 27 |
기술 발표 및 게재
셀투인은 국내외 학회와 학술지를 통해 연구 성과를 지속적으로 발표해오고 있습니다.
Development Technology and senescent Cells : KB. Lee et al., Antioxidants reduce the heterogeneity of the intracellular glutathione level in senescent cell population of human dermal fibroblasts, J Dermatol Sci. (2020) 98(3),195-198
Accumulating evidence suggests that increased reactive
oxygen species (ROS) production has a role in inducing
senescence of human dermal
fibroblasts (HDFs) via the activation
of DNA damage and redox signaling pathways [1]. Unfortunately,
ROS-reducing antioxidant agents are only marginally effective in
delaying or preventing cellular senescence, even at a high
concentration [2,3]. We evaluated endogenous antioxidant
systems to better understand these
findings. Glutathione (GSH)
is the most abundant thiol-containing tripeptide that plays a
major role in eliminating H2O2 through a GSH peroxidase-
catalyzed reactions [4]. Moreover, GSH reduces oxidized proteins
through glutathionylation, thereby regulating the intensity and
duration of redox signaling. Thus, intracellular GSH level are
critical for maintaining redox homeostasis. Measuring GSH level
in live cells is challenging owing to the irreversible reaction of
fluorescent probes with GSH. We developed a new coumarin-
based GSH probe, FreSHtracer, which reversibly reacts with GSH
accompanied by spectral shifts in UV absorption (520 to 430 nm)
and
fluorescence emission (F580 to F510), allowing ratiometric
measurement of GSH in live cells [5]. Here, we monitored the
changes in GSH levels in HDFs during senescence and evaluated
the effect of antioxidants on GSH levels by measuring the F510/F580
ratio (FR).
oxygen species (ROS) production has a role in inducing
senescence of human dermal
fibroblasts (HDFs) via the activation
of DNA damage and redox signaling pathways [1]. Unfortunately,
ROS-reducing antioxidant agents are only marginally effective in
delaying or preventing cellular senescence, even at a high
concentration [2,3]. We evaluated endogenous antioxidant
systems to better understand these
findings. Glutathione (GSH)
is the most abundant thiol-containing tripeptide that plays a
major role in eliminating H2O2 through a GSH peroxidase-
catalyzed reactions [4]. Moreover, GSH reduces oxidized proteins
through glutathionylation, thereby regulating the intensity and
duration of redox signaling. Thus, intracellular GSH level are
critical for maintaining redox homeostasis. Measuring GSH level
in live cells is challenging owing to the irreversible reaction of
fluorescent probes with GSH. We developed a new coumarin-
based GSH probe, FreSHtracer, which reversibly reacts with GSH
accompanied by spectral shifts in UV absorption (520 to 430 nm)
and
fluorescence emission (F580 to F510), allowing ratiometric
measurement of GSH in live cells [5]. Here, we monitored the
changes in GSH levels in HDFs during senescence and evaluated
the effect of antioxidants on GSH levels by measuring the F510/F580
ratio (FR).
학술지 게재
『Stem Cell Report』 | |
『The Journal of Clinical Investigation』 | |
『Science Advances』 |
기술 발표
국제줄기세포학회 기술 발표 |