在全球生物市场利用特有技术积极开展事业
细胞批量培养技术 + 质量管理技术
兼具两种核心技术的企业
获得主导新药开发市场的
主要国家的专利
利用专利技术开拓国际市场
知识产权
我们通过建立知识产权保护核心技术
| 技术名称 | 申请国家 | 申请·注册号 | 申请·登记日期 |
|---|---|---|---|
| 用于检测细胞硫醇水平的 实时成像传感器 |
韩国 | 10-1862581 | 2018. 05. 24 |
| 美国 | 10.215.757B2 | 2019. 02. 26 | |
| 韩国 | 10-1983803 | 2019. 05. 23 | |
| 美国 | 10.620.215 | 2020. 04. 14 | |
| 细胞器内谷胱甘肽检测用 实时荧光成像传感器及其制造方法 |
韩国 | 10-2133794 | 2020. 07. 08 |
| 加拿大（申请） | 3.072.434 | 2020. 02. 07 | |
| 澳大利亚（申请） | 2018320601 | 2020. 02. 19 | |
| 美国（申请） | 16/640717 | 2020. 02. 20 | |
| 欧洲（申请） | 18848372.1 | 2020. 02. 21 | |
| 中国（申请） | 201880054675.0 | 2020. 02. 21 | |
| 印度（申请） | 202017007994 | 2020. 02. 25 | |
| 日本（申请） | 2020-511502 | 2020. 02. 19 | |
| 内质网内谷胱甘肽检测用 实时荧光成像传感器及其使用方法 |
韩国 | 10-2019-0178260 | 2019. 12. 30 |
Gene Biomarker
| 技术名称 | 申请国家 | 申请·注册号 | 申请·登记日期 |
|---|---|---|---|
| 基于 FreSHtracer 分离的细胞 基因配置文件的应用 |
PCT | PCT/KR 2018/008239 | 2018. 07. 20 |
Stem Cell Therapy
| 技术名称 | 申请国家 | 申请·注册号 | 申请·登记日期 |
|---|---|---|---|
| 用于治疗血小板减少症的组合物 | 韩国 | 10-2021-0063975 | 2021. 05. 18 |
| 用于评估干细胞特性的 基因标记及其用途 |
韩国 | 10-2020-0180455 | 2020. 12. 22 |
Cell Quality Control
| 技术名称 | 申请国家 | 申请·注册号 | 申请·登记日期 |
|---|---|---|---|
| 通过实时检测谷胱甘肽， 提高治疗用细胞质量的方法 |
韩国 | 10-2119714 | 2020. 06. 01 |
| 欧洲（申请） | 18883520.1 | 2020. 05. 27 | |
| 中国（申请） | 201880077266.2 | 2020. 05. 28 | |
| 日本（申请） | 2020-546264 | 2020. 05. 27 | |
| 美国（申请） | 16/767985 | 2020. 05. 28 | |
| 通过实时检测谷胱甘肽， 检测治疗用细胞质量的方法 |
韩国 | 10-2145929 | 2020. 08. 12 |
| 美国（申请） | 16/768014 | 2020. 05. 28 | |
| 欧洲（申请） | 18884812.1 | 2020. 05. 27 | |
| 中国（申请） | 201880077236.1 | 2020. 05. 28 | |
| 日本（申请） | 2020-546265 | 2020. 05. 27 |
发表
接连在知名学术期刊上发表了研究成果
Principles of Development Technology : EM. Jeong et al., Real-Time Monitoring of Glutathione in Living Cells Reveals that High Glutathione Levels Are Required to Maintain Stem Cell Function, Stem Cell Reports (2018), 10, 600-614
The core functions of stem cells (SCs) are critically regulated by their cellular redox status. Glutathione is the most abundant non-protein
thiol functioning as an antioxidant and a redox regulator. However, an investigation into the relationship between glutathione-mediated
redox capacity and SC activities is hindered by lack of probe. Here, we demonstrate that cyanoacrylamide-based coumarin derivatives are
ratiometric probes suitable for the real-time monitoring of glutathione levels in living SCs. These probes revealed that glutathione levels
are heterogeneous among subcellular organelles and among individual cells and show dynamic changes and heterogeneity in repopulating
SCs depending on oxidative stress or culture conditions. Importantly, a subpopulation of SCs with high glutathione levels exhibited
increased stemness and migration activities in vitro and showed improved therapeutic efficiency in treating asthma. Our results indicate
that high glutathione levels are required for maintaining SC functions, and monitoring glutathione dynamics and heterogeneity can
advance our understanding of the cellular responses to oxidative stress.
thiol functioning as an antioxidant and a redox regulator. However, an investigation into the relationship between glutathione-mediated
redox capacity and SC activities is hindered by lack of probe. Here, we demonstrate that cyanoacrylamide-based coumarin derivatives are
ratiometric probes suitable for the real-time monitoring of glutathione levels in living SCs. These probes revealed that glutathione levels
are heterogeneous among subcellular organelles and among individual cells and show dynamic changes and heterogeneity in repopulating
SCs depending on oxidative stress or culture conditions. Importantly, a subpopulation of SCs with high glutathione levels exhibited
increased stemness and migration activities in vitro and showed improved therapeutic efficiency in treating asthma. Our results indicate
that high glutathione levels are required for maintaining SC functions, and monitoring glutathione dynamics and heterogeneity can
advance our understanding of the cellular responses to oxidative stress.